IBX5980432E7F390 Various Causes Mother Contains Baby Down Syndrome - Youtube 4 Design

Various Causes Mother Contains Baby Down Syndrome



Down syndrome is the most common genetic chromosome disorder . This condition causes a learning disability in children.

Quoting from Kompas.com , the incidence of Down syndrome, or Down syndrome worldwide is estimated to reach 1: 700 birth rates, aka approximately 8 million children with Down syndrome. Based on the results of the survey in 2010, people with Down syndrome in Indonesia reached more than 300.000 children.

Down syndrome is generally not a hereditary disease. Down syndrome (DS) is a genetic disorder that occurs when the baby is conceived to have an additional chromosome 21, either full or partial copies, which are formed during the development of an egg, sperm, or embryo.
How can Down syndrome occur?

Quoted from mayoclinic.org , about 4% of children with DS have two full copies and one partial copy of chromosome 21 attached together on a different chromosome, referred to as Down syndrome translocation. Down syndrome translocation is the only type of DS that can be derived from either parent. However, only one-third of DS transplant cases are inherited from one parent.

A carrier may show no signs or symptoms of DS, but it may decrease the translocation process to the fetus, causing additional genetic material from chromosome 21.

The risk of decreasing the translocation DS will depend on the gender of the chromosome 21 parent who has been rearranged:
If the father is a carrier , the DS risk is about 3%
If the mother is a carrier , the DS risk ranges from 10-15%
Am I at risk of having a Down syndrome baby?

Although researchers already know how DS occurs, they still do not know much about why this condition can happen. This can make it difficult to understand whether you are at risk of having a baby with Down syndrome.

"Some theories argue that Down syndrome is triggered by how well the body metabolizes folic acid, but many also oppose this theory, because there are so many confusions about factors that affect the occurrence of Down syndrome," says Kenneth Rosenbaum, MD, head of the genetic and metabolic divisions and deputy director of the Down Syndrome Clinic at Children's National Medical Center in Washington, DC, quoted by parents.com .

Certain things can increase your risk of having a baby with Down syndrome, called a risk factor. Risk factors may differ for each type of Down syndrome, but generally include:
1. Age of mother during pregnancy

Down syndrome can occur at any age you are pregnant, but this opportunity will increase with age. The risk of having a baby with genetic problems, including DS, is believed to increase as the woman reaches 35 years of age or older when entering her pregnancy. Women aged 25 years during pregnancy have a risk of 1: 1,200 to have a baby DS, while women aged 35 years during pregnancy have a risk of up to 1: 350. In a 49-year-old pregnant woman, the risk increases to 1:10. However, now many children with DS are born from women aged less than 35 years, due to increased birth rates at a young age.

They found that in women's wombs approaching menopausal age and the risk of infertility also increased, the ability to select the defective embryo decreased and increased the risk of the child it contained would suffer a complete developmental decline. Both researchers believe that these selection selection abilities are women's adaptive responses and may explain why DS tends to increase as women age.
2. Never had a baby Down syndrome before

Women who have had a fetus with DS have a 1: 100 risk to have a later baby also have DS.
3. The number of siblings and the distance of birth

According to research by Markus Neuhäuser and Sven Krackow, of the Institute of Medical Informatics, Biometry and Epidemiology at the University Hospital Essen, Germany, the risk of a baby born with DS also depends on how many siblings are and how big the youngest child is between the youngest. The risk of having a baby with DS is higher in women who are pregnant for the first time at older ages. This risk will also increase when the distance between pregnancies even further.
How do I know if I have a Down syndrome baby?

The American College of Obstetricians and Gynecologists recommends doctors perform prenatal screening and diagnostic tests for DS and other genetic disorders for patients at high risk for DS. However, now all doctors are expected to recommend both of these tests for all women who are planning a pregnancy.

At week 11-14 gestational age, the doctor will run a blood test combined with ultrasound, which checks the fetal back neck thickness (aka nuchal translucency ). Both of these procedures can detect the DS up to 82-87 percent, with minimum risk to yourself as well as the fetus.

If you are 35 or older and are known to have other risk factors, your doctor will also recommend you to run a fetal DNA test during the first trimester of pregnancy. This test has 99 percent accuracy results, because this test will sort the small parts of your fetal DNA circulating in your blood during pregnancy.

In your second trimester, other blood tests (multiple marker screening, or quad screening) can detect DS up to 80% accuracy.

If any of these tests indicate high risk, you can run diagnostic tests, such as amniocentesis or chorionic villus sampling (CVS). It should be understood that these two procedures carry the risk of miscarriage, even though it is low.
Down syndrome can not be prevented

Deciding whether or not you want to run screening is a personal choice that concerns not just your future, as well as your baby. However, the series of tests may also help your doctor to know for sure whether the fetus in your womb has other potential life-threatening issues, such as congenital heart disease.

The magnitude of your baby's risk of Down syndrome, understand that the DS has occurred before conception takes place.

"There's nothing you can do during pregnancy, which will increase or prevent your baby's risk of Down syndrome," says Rosenbaum. The best thing you can do is to run a healthy diet, take prenatal vitamins, and enrich your knowledge of Down syndrome to prepare yourself for all possibilities.

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